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L-tryptophan boosts serotonin in the central nervous system, but has not benefitted my patients.Some websites advertise supplements that increase glutathione, a liver detoxifier, as an antidote.My clinical observation is that long lasting symptoms occur even in patients who taper very slowly, not just those who stop quickly, and that there is no guarantee that these symptoms will go away no matter how long the patient waits.What I have observed is that the ‘withdrawal’ symptoms occur while patients are on a steady dosage of the drug, shortly after stopping the drug and weeks or months after stopping the drugs.Outside of using a benzodiazepine, I don’t have a lot of suggestions.

I expect that the same is true for SSRI withdrawal.The incidence of the late-onset and longer-term symptoms is not known because there has been no systematic study of the problem.Absent a meaningful treatment for the withdrawal emergent symptoms, proper informed consent before starting OR stopping the SSRIs is critical.TD is generally associated with antipsychotic medication, and is also a manufacturer labeled side effect of the SSRIs.TD occurs while on antipsychotics, primarily occurs shortly after stopping them, and may occur months or even longer after stopping the drugs.

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